Specialist services to the pharma and related industries
The Tablet Press
What is the best pointer to making a process scalable?
Processes often fail because the R&D process parameters are not sufficiently realistic. Realistic but not quite on the mark.
Tablets developed in R&D using a pressing forces at the upper end of the pressing force range may be a problem when the dwell time is dramatically reduced in full scale production. The offset for short dwell time is the application of higher pressing forces. What margin has been left below the max. pressing force? The outcome is an inability to reach both hardness and speed of production. If this is becoming your production problem use of more precompresion may help.
It is obviously easier to create this issue when R&D is done on a non-instrumented press.